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Computational biology, including machine-learning algorithms for lactylation-site prediction and bioinformatic tools linking histone lactylation to gene-expression signatures, is now indispensable for mining multi-omics datasets and generating testable hypotheses (112)

However, the small cohort size contributed to underpowered statistical analysis and marked heterogeneity among patients, emphasizing the need for additional CMD trials in expanded cohorts

1 It is noteworthy that the absolute number of breast cancer cases is increasing in many developing countries due to population growth and the adoption of western lifestyles

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[8] Recently, it has been reported that allosteric regulation of core proteins can inhibit HBV replication and the formation of new cccDNA [9, 10]