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Start: Begin at 50 mg once daily to gauge tolerability (watch for flushing or GI upset)

In deeply anaesthetised rats (placed in ventral position) the tail was transected with a surgical scalpel 3 cm from the tip (and submerged into a tube with 15 ml of saline at room temperature in vertical position) and the duration and amount of bleeding were measured to evaluate the hemostatic effect of the agents or saline administration

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Some advanced researchers even purge vials with nitrogen or argon gas after each use, displacing the oxygen with inert gas