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The authors suggest that the radical-scavenging ability of thiamine does not appear to correlate with its effects on microsomal lipid peroxidation

Moreover, this drug also elevated striatal dopamine, which is independent of impulse flow or exocytosis

Loading Dose When the time to reach steady state is appreciable, as it is for drugs with long half-lives, it may be desirable to administer a loading dose that promptly raises the concentration of drug in plasma to the target concentration