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A: Likely, yes

Signs include: Hives or widespread rash beyond the injection site Swelling of face, lips, tongue, or throat Difficulty breathing or wheezing Rapid heartbeat Feeling faint or losing consciousness These symptoms require immediate medical attention

Fragments of mitochondrial DNA released into the extracellular space or circulation, typically during cellular stress, necrosis or mitochondrial damage

how mitochondrial-derived signals (e.g., specific lipids, peptides, or ROS subsets) propagate to regulate cytoplasmic iron metabolism, lipid peroxidation, or antioxidant systems remains elusive

Following immunization, we observed a significant increase in anti-RBD IgG antibody titers in the combination group compared to the vaccine alone group on week 2 and week 5 post-first immunization