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Excessive unbuffered ROS levels damage mitochondria, leading to less ATP and more ROS production, which creates a potential third self-sustained inflammatory loop

Proceedings of the European Society for the Study of Drug Toxicity 7, 17184

Intracellularly, CHAC1 enzymatically degrades GSH into 5-oxoproline and Cys-Gly, acting as a pro-ferroptotic execution signal by accelerating GSH exhaustion 151