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Vitamin B12 is essential for folate utilization, and its absence results in a functional folate deficiency

It carries concentrated growth factors that support faster, more visible healing and better serum absorption right where the skin needs it

To overcome these challenges, researchers have explored advanced formulations, including nanoparticles, micelles, and cyclodextrin complexes, which aim to improve solubility and absorption [19]

However, in 2006 the FDA proposed a ban on the use of hydroquinone in over-the-counter (OTC) skin products because it can cause permanent discoloration of the skin, and moreover is a suspected carcinogen