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The data below is also based on anecdotal evidence from IGF-1 DES experiments

(PubMed) Lahner E, Persechino S, Annibale B

Tolerance develops through repeated exposure

Gazit S, Shlezinger R, Perez G, Lotan R, Peretz A, Ben-Tov A, Herzel E, et al

Precision-medicine frameworks now aim to classify PD patients into microbiome-immune subtypes, allowing for specific combination therapies, such as pairing SCFA-restoring strategies with T-cell modulation in Th17-dominant endotypes or combining barrier-repair interventions with microglial inhibitors in patients with strong peripheral-to-central inflammatory coupling