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For instance, they may modulate the activity of essential enzymes, alter the conformation of proteins, or disrupt clearing pathways

In fact, several related observations suggest that endogenous melatonin acts to counter undesirable abrupt changes in phase

As a result, c-MYC induced reprogramming of mitochondrial metabolism by diverting glucose away from the TCA cycle and leaving cells susceptible to glutamine addiction to sustain anaplerosis

Addressing these areas will not only deepen the understanding of ferroptosis in RCC but also accelerate the translation of ferroptosis-targeted strategies into effective, personalized therapies for this lethal disease