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JNCI: Journal of the National Cancer Institute

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They found a strong link between B12 levels and iron markers like serum iron and ferritin

When High B12 Status May Not Mean More Is Needed If routine blood work shows your B12 levels are at the high end of the normal range or above it, this is a clear signal that additional supplementation is physiologically unnecessary

Later, in the 1980s, the development of high-pressure liquid chromatography methods allowed for rapid determination of homocysteine concentrations in 1000s of samples, thus paving the way for epidemiological studies that revealed significant associations between relatively small elevations of homocysteine in blood and cardiovascular, cerebrovascular, and peripheral vascular diseases (7, 46)