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436 A recent meta-analysis of 43 randomized controlled trials involving adult subjects with acupuncture for MDD demonstrated that acupuncture, either alone or in combination with antidepressants, significantly reduced the hamilton depression scal scores and had fewer adverse effects compared to antidepressants, however, further rigorous experiments are still required to determine the optimal frequency of acupuncture for MDD in order to achieve better efficacy

J., Huber, K

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Neuroprotective effect of 6-Paradol in focal cerebral ischemia involves the attenuation of Neuroinflammatory responses in activated microglia

Additionally, in the randomized-controlled trial, the diabetes drug metformin (activator of AMPK) initiated within 7 days of SARS-CoV-2 infection reduced the risk of LC by 41% (131)