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J Comp Neurol 344:119 Smith Y, Raju DV, Pare JF et al (2004) The thalamostriatal system: a highly specific network of the basal ganglia circuitry

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This is fundamentally different from the injection site profile of tirzepatide or semaglutide , which generally produce minimal injection site reactions

Signs that warrant evaluation include: pain radiating down the arm or leg persistent numbness muscle weakness worsening symptoms over time Imaging and a physical examination help determine the underlying cause of the problem