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This is accompanied by a shift in macrophage populations, with a higher number of pro-inflammatory M1 macrophages and reduced anti-inflammatory M2 macrophages in Hunner lesions

It delays the onset of ALS, increases the survival of spinal motor neurons, preserves the function of the lower and upper motor neuron (Mancuso et al., 2014a, b), attenuates the loss of motor neurons and improves muscle atrophy and mitochondrial function of muscle fibers in a SOD1 G93A mouse model of ALS (Song et al., 2014) (Table 1)