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Genetic influence on vascular smooth muscle cell apoptosis

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While initially activated by their pro-inflammatory microenvironment, at a certain stage, fibroblasts acquire an epigenetically imprinted aggressive phenotype switching from responders to drivers, and hence switching the disease from acute to chronic ( in vivo

3.3 Oxidative stress Oxidative stress generally refers to a state of imbalance between oxidation and antioxidant defense system (126)