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An anemic individual cannot efficiently convert fats and proteins into energy

Preclinical studies demonstrate improvements in tendon-to-bone healing, with enhanced collagen organization and increased tensile strength in healed tissues

However, forward genetics suffers from low efficiency in identifying new genes and pathways, as mutations are randomly induced, making it challenging to study specific genes or pathways, and the understanding of the functional significance of identified genes is limited

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continuation beyond three to six months depends on symptomatic benefit and laboratory confirmation of necessity, and therapy may be indefinite when tolerated and beneficial