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The glutathione redox cycle, demonstrating the inter-conversion of oxidized and reduced glutathione GLUTATHIONE AND HUMAN PIGMENTATION : Melanin in human skin is a polymer of various indole compounds synthesized from L-tyrosine by the RaperMason pathway of melanogenesis [Figure - 2] with tyrosinase being the rate limiting enzyme

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Vitamin C (ascorbic acid) is a premier water-soluble antioxidant that circulates throughout the bloodstream, scavenging reactive oxygen species (ROS) and protecting immune cells from the oxidative damage generated during an immune response

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Both nutrients exert antidepressant effects through gut microbiota regulation, either by enhancing SCFA production or reducing inflammation, making them the most promising candidates for clinical translation (consistent with Sections 4.3, 5.3)

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In support of this notion is our observation that sVLDLR, the soluble extracellular domain of VLDLR without the transmembrane and intracellular domains, can rescue the metabolic disturbance (Supplementary Fig

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