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At first evaluation, DXA confirmed osteoporosis: L1L4 BMD = 0.748 g/cm 2 ,T-score = 3.6SD, Z-score = 2.3SD, total hip BMD = 0.638 g/cm 2 , T-score = 3SD, Z-score = 2SD with an improvement after 4 y to L14 BMD = 0.821 g/cm 2 , T-score = 3SD, Z-score = 1.3SD, total hip BMD = 0.702 g/cm 2 , T-score = 2.4SD, Z-score = 0.9SD, but she suffered a double patellar fracture that was considered a fragility fracture

In a double-blind RCT, individuals using NAC 400 mg twice daily had a lower relapse rate than those taking a placebo while decreasing prednisolone [70]

Visible fading of dark spots and more even tone typically appears after 24 weeks of consistent daily use

This difference is based on their pharmacokinetics

& Chipman, J