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Manuel Schtzer works for SIPCAN Special Institute for Preventive Cardiology and Nutrition, an NGO working in preventative healthcare

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Emerging evidence has found that tubulointerstitial fibrosis is mostly impacted by epithelial-mesenchymal transition (EMT) where proximal tubular epithelial cells exhibit a fibroblast-like phenotype characterized by the absence of apical polarity and E-cadherin expression and the presence of mesenchymal cell markers 6,7