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The hydroxyl radical induces the formation of DNA-protein cross-links, single- and double-stranded breaks, lipid peroxidation, and protein fragmentation

Upon hypoxia, HIF-1 is stabilized and translocates to the nucleus, where it dimerizes with HIF-1, binds to target genes, and activates gene transcription

MI has been employed effectively as the method of choice in most BCI-NFT systems

Carmo, M

Another effect of AT1 receptor overstimulation is the activation of NOX5, NF-B, IL-6 and STAT3, which exacerbates oxidative stress and causes overproduction of pro-inflammatory cytokines (including IL-6, IL-1 and TNF-) (268, 275277)