DOI: 10.1038/s41598-024-64368-y Du X et al
Biomaterials 222:119451
To date, no approved DSIP drug exists for a defined sleep indication, and large-scale controlled human trials are lacking
Why NAC rather than glutathione directly
Abbreviations FDA: Food and Drug Administration WHO: World Health Organization USDA: United States Department of Agriculture USD: United States Dollar ISO: International Standard Organization FAOSTAT: Food and Agriculture Organization Corporate Statistical Database USA: United States of America UK: United Kingdom FAO: Food and Agriculture Organization EU: European Union FDA: Food and Drug Administration FASSAI: Food Safety and Standard Authority of India GRAS: Generally Recognised as Safe COX: Cyclooxygenase EO: Essential oil COVID-19: Corona Virus Infectious Disease 2019 HIV-AIDS: Human immunodeficiency virus- acquired immune deficiency syndrome ECM: Extracellular matrix HCA: Hydroxycitric acid AgNPs: Silver nanoparticles GC MS: Gas chromatography mass spectrometry ATCC: American type culture collection DETS: Diethylthiosulfinate DMTS: Dimethylthiosulfinate DATS: Diallylthiosulfinate DPTS: Dipropylthiosulfinate DBTS: Dibenzylthiosulfinate DTS: Diallyl trisulfide PCSO: S-propyl-cysteine-sulfoxide MCSO: S-methyl- cysteine-sulfoxide DAS: Diallyl sulfide DDS: Diallyl disulfide MIC: Minimum inhibitory concentration MFC: Minimum fungicidal concentration TEM: Transmission electron microscope AMS: Allyl methyl sulfide CLSI: Clinical Laboratory Standard Institute g/mL: Microgram per millilitre SEM: Scanning electron microscope L: Microlitre BALB/c: Baggs albino CFU: Colony forming unit MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ROS: Reactive oxygen species TPP: Triphenylphosphonium EOCS: Essential oil of cumin seeds VVC: Vulvovaginal candidiasis AmB: Amphotericin B NCPF: National collection of pathogenic fungi CBEO: Cinnamon bark essential oil CLEO: Cinnamon leaf essential oil CEO: Cinnamon essential oil RNA seq: RNA sequencing qrt-PCR: Quantitative real time polymerase chain reaction FLU: Fluconazole IL-1: Interleukin-1 TNF-: Tumor necrosis factor IL-17: Interleukin-17 NCIM: National collection of industrial microorganism SOD: Superoxide dismutase GPx: Glutathione peroxidase CAT: Catalase GLT: Glutathione transferase GLR: Glutathione reductase CV: Crystal violet ZOI: Zone of inhibition DNA: Deoxyribonucleic acid XTT: 2,3-Bis-(2-methoxy-4-nitro-5-sulphenyl)-2H-tetrazolium-5-carboxanilide CLSM: Confocal laser scanning microscopy PKA: Protein kinase A DS: Denture stomatitis MAPK1: Mitogen activated protein kinase 1 RCT: Randomized clinical trials Cd: Cadmium Pb: Lead Ar: Arsenic ppm: Parts per million FAAS: Flame atomic absorption spectroscopy ICP-MS: Inductively coupled plasma-mass spectrometry ICP-OES: Inductively coupled plasma-optical emission spectroscopy GFAAS: Electrothermal graphite furnace atomic absorption spectroscopy XRFS: X-ray fluorescence spectroscopy MAE: Microwave assisted extraction UAE: Ultrasound assisted extraction SFE: Supercritical fluid extraction mg/mL: Milligram per millilitre References Abd Ellah NH, Shaltout AS, Abd El Aziz SM, Abbas AM, Abd El Moneem HG, Youness EM, Abd El-hamid BN (2021) Vaginal suppositories of cumin seeds essential oil for treatment of vaginal candidiasis: Formulation, in vitro, in vivo, and clinical evaluation
