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Ethical approval and consent to participate All experiments utilizing animal models conducted in our laboratory and referred to in this review adhered to the Guidelines for the Care and Use of Laboratory Animals as required by the National Institutes of Health (NIH Publication No

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151 MAPK promotes cell proliferation in PH In patients with PAH, abnormal activation of the MAPK pathway leads to excessive proliferation and disrupted apoptosis in PASMCs and PAECs, contributing to pulmonary vascular remodeling

Moreover, madecassoside (MAD), isolated from Centella asiatica (Li et al., 2016) could repress the activation of the HGF-induced c-Met-PKC-ERK1/2-Cyclooxygenase-2 (COX-2)-Prostaglandin E2 (PGE2) cascade to inhibit HCC cell proliferation and invasion

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