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Serums and Moisturizers: Apply serums containing brightening agents, such as vitamin C or niacinamide

Rational use of inhaled corticosteroids for the treatment of COPD

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Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization