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Although these formulations offered symptomatic relief, limitations such as poor skin penetration, short shelf life, and variability in preparation led to the development of modern, standardized and nanotechnology-enhanced herbal formulations with improved efficacy and stability [32]

The expression of iNOS is induced by exposure to allergens, pro-inflammatory cytokines (IL-1, IFN-, TNF-), bacterial lipopolysaccharide, and pro-oxidants (92)

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In these studies, researchers assembled a de novo transcriptome of 66,370 contigs from eight tissue libraries exposed to abiotic stress