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Statistical analysis SPSS 23.0 (IBM Corp., Armonk, NY), GraphPad Prism 8.0 (GraphPad Software, La Jolla, CA), and ImageJ software (National Institutes of Health, Bethesda, MD) were used for statistical analyses and drawings

Figure 2D reveals the intricate network of proteins and genes such as APOE, APP, beta-secretase 1(BACE1), and PSEN1 involved in amyloid metabolism and plaque formation

It helps recycle molecules, build new proteins, and support metabolism

For the analysis, we employed ELISA kits provided by Sunlong Biotech Co., China, with the following catalogue numbers: E-CL-R0416 for leptin and E-OSEL-R0006 for adiponectin