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Employing this integrated framework, zebrafish studies have revealed that although many plant-derived constituents are relatively safe (Table 4), certain extracts and purified monomers exhibit significant dose-dependent hepatotoxicity, warranting careful attention (Liu et al., 2017

(2025) Although there is extensive evidence that mechanisms of APAP hepatotoxicity translate to human overdose patients, the vast majority of experiments are performed in young and healthy male mice, which does not reflect the entire spectrum of patients in terms of age, sex, pre-existing conditions, consumption of multiple drugs, etc

SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells

Gradually increase usage after a week, ensuring there is no irritation

Dimethyl fumarate induces ferroptosis and impairs NF-kappaB/STAT3 signaling in DLBCL