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The final breakthrough of levodopa substitution was achieved after the neurologist George Cotzias described the transforming clinical effects of oral levodopa [12]

J Pers Med 12:352 Marengo-Rowe AJ (2007) The thalassemias and related disorders

The heatmap (Supplementary Figure S1) showed distinct clustering between the two treatment groups, further confirming that the observed metabolic alterations were specific to A45 exposure