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Apr 2016;87(4):367-72

This brings us to the concept of bioavailability

PC cells require excess zinc to support proliferation and, on the other hand, avoid the adverse effects of zinc through other regulatory mechanisms

1996, Wheatley et al

Circulating concentrations of choline and betaine and risk of cardiovascular disease A 1995 study had found that elevated blood homocysteine concentrations in patients who experienced a vascular occlusion were associated with higher urinary excretion of betaine, rather than with reduced intake of choline or betaine or diminished activity of BHMT (49)