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One approach in creating a mitochondria-targeted AT is to bind an antioxidant molecule (e.g., SOD, thiol, vitamin E, BHT, ebselen, CoQ, or various spin traps, such as TEMPO) with a hydrocarbon chain of varying length to the phosphorus of the lipophilic compound triphenylphosphonium (TPP) such as mitoquinol (MitoQ 10

In addition, increasing the stability of the cannabinoid using alcoholic formulations, as required by the physico-chemical characteristics of these compounds, is not recommended for applications to the skin, especially in dermatological conditions [174,213]

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Factors that contribute to these variations include an individual's baseline glutathione levels, skin type, lifestyle, the specific skin concerns being addressed, and the consistency of treatments