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FIGURE 1 Cell culture The cell line of HRMCs was purchased from the Chinese Academy of Sciences, Shanghai Institute for Biological Sciences Cell Resource Center

CCI: chronic constrictive injury

We then utilized this DeepContrast technique to study brain aging and Alzheimer's disease, applying it to both in-house datasets from an aging study, as well as to the publicly available ADNI dataset from Alzheimer's patients and age-matched controls

Its long research history and broad range of applications have helped make it one of the most established peptides available today

Notably, we observed lower levels of tissue coenzyme A (CoA), which has been considered to be extremely stable 10 , resulting in reduced mitochondrial functionality and metabolic rewiring