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Elevated nitric oxide (NO), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1, TNF-, IFN-) further inhibit SLC7A11 and destabilize GPX4 activity in cancer cells

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pylori lipopolysaccharide (LPS) rely on stimulation by phosphatidylinositol 3-kinase (PI3K), which is contingent on the PLC/PKC signaling pathway (113)

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