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LPS are the endotoxins released by bacteria that can promote inflammation

FIGURE 2 Other detrimental markers of inflammation were studied to confirm the efficacy of HU

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The complex interaction relationship between iron metabolism disorders and changes in the abundance of gut microbiota (especially Bifidobacterium ) revealed in this section provides evidence for clarifying the molecular mechanism of the hypothetical pathological axis of iron overload-disruption of gut homeostasis-ferroptosis in OA, and suggests that targeted regulation of the iron-microbiota interaction may become a potential new strategy for the prevention and treatment of OA