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For this reason, obesity is strongly associated with type 2 diabetes

Regarding the specific topic of uremic toxins, different studies have demonstrated that uremic toxins, such as indoxyl sulfate [253], acrolein [254], indole-3-acetic acid [255], urea, and p -cresol [256], may directly prompt eryptosis

Acknowledgements We thank all the authors for their critical reading of the manuscript and for the helpful discussions

These findings suggest that after the loss of dopaminergic neurons, a vicious cycle of decreased dopamine releaseDRD2 signaling deficiencydecreased GSH synthesisoxidative stressdopaminergic neuron death will occur, leading to GSH deficiency and the progression of PD

Yesfoods rich in sulfur, antioxidants, and protein provide the building blocks, but supplementation may help in cases of depletion