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[599] underscore the need for large-scale targeted mechanistic studies, such as longitudinal gut-microbiome profiling, in vivo models of -synuclein propagation, and integrated immunemetabolite analyses, to elucidate pathways along the gutbrain axis

Next-generation sequencing data are publicly available in the Gene Expression Omnibus GEO database under accession number GSE157491, Funding: This study was supported by the College of Human Sciences Intramural Collaborative Grant (SC, KS, MR, TD, MK, RV, EM) and the Presidential Interdisciplinary Research Seed Grant Program (KS, SC, MR, TD, MK, RV, EM) at Iowa State University

Moreover, recent frameworks extend these strategies to inflammatory and pulmonary diseases, where similar trigger-based principles guide the rational selection of linkers and cross-linking chemistries for in vitroin vivo correlation (Kalkal et al., 2025

Saleh EM, El-awady RA, Eissa NA, Abdel-Rahman WM

Effects of supplementation with omega-3 fatty acids during pregnancy on asthma or wheeze of children: a systematic review and meta-analysis