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Metformin, an AMP-activated protein kinase (AMPK) activator widely used in diabetes, is currently in phase I clinical trials for heart failure with preserved ejection fraction (HFpEF) (Tables 1 and 2)

Nat Chem Biol 15(12):11371147 Zheng Y, Sun J, Luo Z, Li Y, Huang Y (2024) Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications