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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations ABD, adynamic bone disease

although antagonism of doxorubicin and/or etoposide was observed with emodin, rhein and cis -stilbene, this occurred in the presence of unchanged or elevation of GSH levels

Furthermore, diminished METTL3 expression in MSCs reduces protein synthesis of parathyroid hormone receptor-1 (Pth1r), thus decreasing translation efficiency and suppressing the activation of protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) pathways, leading to reduced osteogenic differentiation [92]

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Without Ribose the process of energy synthesis grinds to a halt