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Melatonin reduces cardiac morbidity and markers of myocardial ischemia after elective abdominal aortic aneurism repair: a randomized, placebo-controlled, clinical trial

Abstract Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO - ) generation during aging

This action reduces insulin resistance and helps regulate blood glucose levels, potentially mitigating hyperglycemia that contributes to nerve damage in DPN [39,69,85]