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For example, FDA labeling for cyanocobalamin injection includes contraindications (such as hypersensitivity) and important warnings (see the FDA prescribing information for cyanocobalamin injection )

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Consequently, any factor inhibiting SLC7A11 function or downregulating its expression leads to intracellular GSH depletion, thereby depriving GPX4 of its essential substrate and ultimately triggering irreversible ferroptosis

doi: 10.1007/s10048-010-0259-0 273 Santos-NetoJ