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Intriguingly, dextran sulfate sodium (DSS)-induced mice colitis daily intraperitoneal injection with 0.5 mL of APS (200 mg/kg) for 3 days remarkedly reduced phosphorylation level of NF-B and downregulated the mRNA expression of TNF-, IL-1, IL-6, and IL-17 (116)

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This expression of G9a and DNMT1 is required for TGF-1-induced activation of HSC fibrosis, and the first dual G9a/DNMT1 inhibitor, CM272, represents a novel pharmacological agent for targeting DNMT1 and G9a to counteracts the TGF-1-induced pro-fibrotic response and metabolic reprogramming of HSCs [59]

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