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The clinical perspective tends to consider data on efficacy, safety, and patient outcomes when selecting between peptide therapies

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PRMT5 increased at the early stage and then decreased at the later stage, while PRMT1 first decreased and then increased, which was regulated by an inflammation activated E3 ubiquitin ligase PELI1

The Poisson correction method (Zuckerkandl and Pauling, 1965) was employed to calculate evolutionary distances, expressed in units of the number of amino acid substitutions per site