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Follow-up analyses indicated that age was positively associated with insomnia among patients prescribed AMP ER ( r = 0.206, p = 0.001) and showed a similar nonsignificant trend for LDX ( r = 0.127, p = 0.069), whereas age was negatively associated with insomnia among patients prescribed SDX/d-MPH ( r = 0.331, p = 0.009)

We have further monitored the structural details at a range of pHs (pH 2.010.0) to further unfold the pH-induced structural alterations by measuring far UV CD and tryptophan fluorescence (Supplementary Fig