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It's important to emphasize: virtually all of this research has been conducted in animal models

Physician 47 (1), 79 55 Vidal-AlaballJ.ButlerC.HoodK.CanningsR.McCaddonA.PapaioannouA

Findings are mixed and often depend on B-vitamin status, which is why the variant is best understood as one modifiable-context factor rather than a fixed risk