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The evolution of intracellular parasitic lifestyle of Mtb could be in part due to the deletion of the cobF gene and the consequent need to uptake vitamin B12 from the host ( One of the major obstacles in controlling TB is the lack of a rapid but efficient diagnostic tool able to differentiate active TB from LTBI

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Most adults need about 2.4 micrograms per day, but pregnant or breastfeeding women may require more

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