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NNMT Expression in Oncology Research Increased NNMT expression has been documented in several tumor types in preclinical and ex vivo studies, including gastric, pancreatic, renal, and bladder cancer models

The most advanced is Daratumumab (Janssen Biotech) which received FDA approval for MM in 2015 [41-42]

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Matrix Biol 49:3760 Ehren J, Moron B, Martin E, Bethune MT, Gray GM, Khosla C (2009) A food-grade enzyme preparation with modest gluten detoxification properties