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17,18 This is the main route involved in the pathogenesis of asthma

Studies have shown that low folate, HHcy, and Mthfr deficiency can disrupt Leucine Carboxyl Methyltransferase 1 (LCMT1)-dependent methylation of protein phosphatase 2 A (PP2A), which is a major Ser/Thr phosphatase essential for neuronal homeostasis [120, 121]