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Lineu Prestes, 748, Cidade Universitria, So Paulo 05508-000, Brazil [email protected] This article was submitted to Chemical Biology, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The main mechanism of ferroptosis Inhibiting the cysteine-glutamate transporter system Xc can induce ferroptosis System Xc is a sodium independent antiporter that export intracellular glutamate and import extracellular cystine across the membrane in a ratio of 1:1 to synthesize glutathione in cells [19]

The best model for phylogeny as determined by MEGA-11 36 was T92+G, based on the lowest Bayesian Information Criterion (BIC) scores

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Four endothelial clusters were identified, and they shared strong expression of Cdh5 and Pecam1 (Extended Data Fig