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The mice were initially engineered by Shao et al

doi: 10.1259/bjr.20220825 55 PortierLDFourmauxPHeinrichBBecerraSFouilladeMBerthaultCet al

The additive effects observed when combining NNMT inhibition with exercise indicate that the compound influences molecular pathways distinct from those activated by physical training alone

This architecture creates an extraordinarily high binding affinity (pK = 16.44), roughly 10 million times stronger than other tripeptides and comparable to albumins copper binding