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Although the precise etiology of PD remains unclear, factors such as oxidative stress, lipid metabolism dysregulation, metal ion metabolic disorders, mitochondrial dysfunction, and glial cell activation are known to contribute to the progression of PD, suggesting that ferroptosis plays a significant role in its pathogenesis (Wang ZL

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Blood-based biomarkers have proven beneficial in clinical practice in other medical specialties because of the ease of access and low invasiveness of the bio-sampling method ( It is not entirely clear how the peripheral Glu, Gln or the mRNA expression levels of NMDAR NR1 subunit reflect CNS levels

The damage to cellular tissue caused by free radicals like reactive oxygen species (ROS) is what leads to oxidative stress and or mitochondrial dysfunction (Rossignol and Frye, 2011[45])