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55,56,57 Recently, the first gene therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology has been approved for marketing, 58 resulting in revolutionary changes in NADs development

These results confirmed the antiviral potential of ivermectin and demonstrated the value of liposomes as effective drug carriers that improve pharmacokinetics and therapeutic outcomes

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Finally, a network meta-analysis incorporating data from 50 randomized placebo-controlled trials involving approximately 20,000 AD patients demonstrated that the administration of melatonin (3 mg/day) over a period of 6 to 12 months was associated with improved cognitive function [226]

In addition to HSCs, in an injured liver, hepatocytes and bile duct cells can also transform into fibroblasts via the process of epithelialmesenchymal transition (EMT), and excessive extracellular matrix (ECM) deposition by fibroblasts contributes to liver fibrosis