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These experiments highlight the complex and highly dynamic redox landscape of the cell, where individual redox couples, even within a single subcellular compartment, often do not equilibrate with each other in vivo

In addition, the dynamic environment of the air-blood barrier makes the cells more sensitive and the barrier more responsive to CS-induced changes

3D, lower right), likely due to the predominant formation of the hyperoxidized form as observed for GPx7 WT in the presence of 200 M H 2 O 2 and 10 M reduced PDI (Fig

Additionally, the CFAX12 lung-on-chip platform is the only system to integrate biomechanical stretch, simulating breathing-like forces, which significantly influence cellular responses to cigarette smoke exposure

10.1056/NEJMoa003417 158 VeseliB