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to 5 mg/kg after dialysis) may be made as early as the third or fourth week of therapy

& Sung, J

Management of increased intracranial pressure is similar to that for any other neurologic disorder causing increased intracranial pressure, including elevation of the head of the bed, hyperventilation (if patient is mechanically ventilated), mannitol, and other diuretics

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These added levels of complexity and the limitations that will need to be overcome to fully understand their implications and implement these insights in targeting AR action for therapeutic intervention could be viewed as challenging