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Evidence emerging during the last few years shows that specific redox-regulated proteins play a pivotal role in protecting bacterial cells from neutrophil-derived oxidative stress

That means developers must initiate programs well before exclusivity expiration to be ready for launch, and they must finance those programs against the risk that the reference product sponsor extends exclusivity through lifecycle management, litigation, or new indication approvals that restart certain protections

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Milner, et.al

Status of New Zealand fresh-water eel stocks and management initiatives